TseG,YeoJM.Conductionabnormalitiesandventriculararrhythmogenesis:Therolesofsodiumchannelsandgapjunctions[J].IJCHeartVasculature,,9:75-82.
Abstract：Ventriculararrhythmiasarisefromdisruptionsinthenormalorderlysequenceofelectricalactivationandrecoveryoftheheart.Theycanbecategorizedintodisordersaffectingpredominantlycellulardepolarizationorrepolarization,orthoseinvolvingactionpotential(AP)conduction.Thisarticlebrie?ydiscussesthefactorscausingconductionabnormalitiesintheformofunidirectionalconductionblockandreducedconductionvelocity(CV).ItthenexaminestherolesthatsodiumchannelsandgapjunctionsplayinAPconduction.Finally,itsynthesizesexperimentalresultstoillustratemolecularmechanismsofhowabnormalitiesintheseproteinscontributetosuchconductionabnormalitiesandhenceventriculararrhythmogenesis,inacquiredpathologiessuchasacuteischaemiaandheartfailure,aswellasinheritedarrhythmicsyndromes.
摘要翻译：室性心律失常是由于心脏正常的电活动的激活和恢复顺序受到扰乱产生的。而心脏正常电活动的扰乱可以分为几类且主要表现在细胞的去极化或复极化或动作电位的传导方面。本文简短的探讨了影响包括单向传导阻滞和降低传导速度在内的传导异常的因素，并叙述了钠离子通道和缝隙连接在动作电位传导中的作用，最后综述了已有的实验结论并阐明了引起传导异常和增加室性心律失常发生的蛋白无论是在包括急性心肌梗死和心衰在内的后天性病理改变还是先天性心律失常综合征中如何改变的分子机制。
