GaryTse,VivianTse,JieMingYeo，etal.AtrialAnti-ArrhythmicEffectsof
HeptanolinLangendorff-PerfusedMouseHearts,PLoSONE,.
Abstract:Acuteeffectsofheptanol(0.1to2mM)onatrialelectrophysiologywereexploredinLangendorff-perfusedmousehearts.Leftatrialbipolarelectrogramormonophasicactionpotentialrecordingswereobtainedduringrightatrialstimulation.Regularpacingat8Hzelicitedatrialactivityin11outof11heartswithoutinducingatrialarrhythmias.ProgrammedelectricalstimulationusingaS1S2protocolprovokedatrialtachy-arrhythmiasin9of17hearts.Intheinitiallyarrhythmicgroup,2mMheptanolexertedanti-arrhythmiceffects(Fisher’sexacttest,P0.05)andincreasedatrialeffectiverefractoryperiod(ERP)from26.0±1.9to57.1±2.5ms(ANOVA,P0.)despiteincreasingactivationlatencyfrom18.7±1.1to28.9±2.1ms(P0.)andleavingactionpotentialdurationat90%repolarization(APD90)unaltered(25.6±1.2vs.27.2±1.2ms;P0.05),whichledtoincreasesinERP/latencyratiofrom1.4±0.1to2.1±0.2andERP/APD90ratiofrom1.0±0.1to2.1±0.2(P0.).Incontrast,intheinitiallynon-arrhythmicgroup,heptanoldidnotalterarrhythmogenicity,increasedAERPfrom47.3±5.3to54.5±3.1ms(P0.05)andactivationlatencyfrom23.7±2.2to31.3±2.5msanddidnotalterAPD90(24.1±1.2vs.25.0±2.3ms;P0.05),leavingbothAERP/latencyratio(2.1±0.3vs.1.9±0.2;P0.05)andERP/APD90ratio(2.0±0.2vs.2.1±0.1;P0.05)unaltered.Lowerheptanolconcentrations(0.1,0.5and1mM)didnotalterarrhythmogenicityortheaboveparameters.Thepresentfindingscontrastwithknownventricularpro-arrhythmiceffectsofheptanolassociatedwithdecreasedERP/latencyratio,despiteincreasedERP/APDratioobservedinboththeatriaandventricles.
摘要：探讨庚醇对Lanendorff灌注的鼠心的心房电生理学的急性作用，左心房双极电极和单相动作电位的记录通过右心房起搏获得。由于11个心脏并没有诱发房性心律失常，以8HZ有规律的起博兴奋11个心脏的心房活性，对于17个心脏中的9只，运用S1S2程控刺激激发房性心动过速。在起初的心律失常组，2mM庚醇用于抗心律失常，增加心房ERP（26.0±1.9to57.1±2.5ms(ANOVA,P0.)），增加激活潜伏期（18.7±1.1to28.9±2.1ms(P0.)），并不改变APD90(25.6±1.2vs.27.2±1.2ms;P0.05)，引起ERP/激活潜伏期增加（1.4±0.1to2.1±0.2）以及ERP/APD90（1.0±0.1to2.1±0.2(P0.)）。相比之下，在最初的非心律失常组，庚醇并不改变心律失常，增加ERP（47.3±5.3to54.5±3.1ms(P0.05)）及激活潜伏期（23.7±2.2to31.3±2.5ms），并不改变APD90(24.1±1.2vs.25.0±2.3ms;P0.05),引起ERP/激活潜伏期(2.1±0.3vs.1.9±0.2;P0.05)以及ERP/APD90(2.0±0.2vs.2.1±0.1;P0.05)并不改变，低浓度庚醇(0.1,0.5and1mM)并不改变心律失常和相关参数，尽管在心房和心室观察到ERP/APD增加，目前的研究结果与已知的庚醇药物性室性心律失常作用相比与增加ERP/激活潜伏期有关。
专门治疗白癜风的医院新疆治疗白癜风医院
